Architecting the cyberinfrastructure for National Science Foundation Ocean Observatories Initiative (OOI)

The NSF Ocean Observatories Initiative (OOI) is a networked ocean research observatory with arrays of instrumented water column moorings and buoys, profilers, gliders and autonomous underwater vehicles (AUV) within different open ocean and coastal regions. OOI infrastructure also includes a cabled array of instrumented seafloor platforms and water column moorings on the Juan de Fuca tectonic plate. This networked system of instruments, moored and mobile platforms, and arrays will provide ocean scientists, educators and the public the means to collect sustained, time-series data sets that will enable examination of complex, interlinked physical, chemical, biological, and geological processes operating throughout the coastal regions and open ocean. The seven arrays built and deployed during construction support the core set of OOI multidisciplinary scientific instruments that are integrated into a networked software system that will process, distribute, and store all acquired data. The OOI has been built with an expectation of operation for 25 years.Peer Reviewe

Guest Editors Introduction: Extreme Data

The guest editors discuss work that can accelerate insights from extreme data, from innovative algorithmic formulations to implementation frameworks and software stacks

Guest Editors Introduction: Cloud Computing

The guest editors discuss this special issue on cloud computing, exploring how cloud platforms and abstractions can be effectively used to support real-world science and engineering applications

Survey and Analysis of Production Distributed Computing Infrastructures

This report has two objectives. First, we describe a set of the production distributed infrastructures currently available, so that the reader has a basic understanding of them. This includes explaining why each infrastructure was created and made available and how it has succeeded and failed. The set is not complete, but we believe it is representative. Second, we describe the infrastructures in terms of their use, which is a combination of how they were designed to be used and how users have found ways to use them. Applications are often designed and created with specific infrastructures in mind, with both an appreciation of the existing capabilities provided by those infrastructures and an anticipation of their future capabilities. Here, the infrastructures we discuss were often designed and created with specific applications in mind, or at least specific types of applications. The reader should understand how the interplay between the infrastructure providers and the users leads to such usages, which we call usage modalities. These usage modalities are really abstractions that exist between the infrastructures and the applications; they influence the infrastructures by representing the applications, and they influence the ap- plications by representing the infrastructures

Acute ST elevation myocardial infarction after intravenous immunoglobulin infusion in a young patient: a rare but probable adverse effect of immunoglobulin

Intravenous immunoglobulin (IVIG) is used in the treatment of a variety of disorders, including autoimmune conditions. IVIG has been considered a safe medication, with minor and transient adverse effects. With the wider use of IVIG, the reported rate of adverse effects has been increased, some of them are potentially fatal cardiovascular reactions due to induction of hypercoagulable state. We report a 40-year-old female treated with IVIG for Guillain-Barre syndrome, who developed chest pain 1 hr following IVIG infusion. The symptoms were associated with ST elevation in anterior leads on electrocardiogram. This anterior wall myocardial infarction (MI) is compatible with IVIG-induced hypercoagulability and considered as a probable adverse effect of this medication. To the best of our knowledge, this is probably the first case report where a young patient developed acute MI without any cardiac risk factors after IVIG infusion